Leukotrienski B4 receptor 1

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Leukotrienski B4 receptor
Identifikatori
SimboliLTB4R; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
Vanjski IDOMIM: 601531 MGI: 1309472 HomoloGene: 22477 IUPHAR: BLT1 GeneCards: LTB4R Gene
Ontologija gena
Molekularna funkcija • nukleotidno vezivanje
• aktivnost leukotrienskog B4 receptora
• aktivnost signalnog prenosnika
• receptorska aktivnost
• aktivnost leukotrienskog receptora
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • komponenta ćelijskog kretanja
• kontrakcija mišića
• inflamatorni respons
• imunski respons
• signalni put G-protein spregnutog receptora
• aktivacija fosfolipaze C
Ortolozi
VrstaČovekMiš
Entrez124116995
EnsemblENSG00000213903ENSMUSG00000046908
UniProtQ15722O88855
RefSeq (mRNA)NM_001143919.2NM_008519.2
RefSeq (protein)NP_001137391.1NP_032545.1
Lokacija (UCSC)Chr 14:
24.78 - 24.79 Mb		Chr 14:
56.38 - 56.39 Mb
PubMed pretraga[1][2]

Leukotrienski B4 receptor 1 je protein koji je kod ljudi kodiran LTB4R genom.[1][2][3]

Reference

  1. ↑ Owman C, Nilsson C, Lolait SJ (Feb 1997). „Cloning of cDNA encoding a putative chemoattractant receptor”. Genomics 37 (2): 187–94. DOI:10.1006/geno.1996.0541. PMID 8921391. 
  2. ↑ Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). „Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells”. J Biol Chem 271 (31): 18363–7. DOI:10.1074/jbc.271.31.18363. PMID 8702478. 
  3. ↑ „Entrez Gene: LTB4R leukotriene B4 receptor”. 

Literatura

  • Raport CJ, Schweickart VL, Chantry D, et al. (1996). „New members of the chemokine receptor gene family.”. J. Leukoc. Biol. 59 (1): 18–23. PMID 8558062. 
  • Tager AM, Luster AD (2004). „BLT1 and BLT2: the leukotriene B(4) receptors.”. Prostaglandins Leukot. Essent. Fatty Acids 69 (2-3): 123–34. DOI:10.1016/S0952-3278(03)00073-5. PMID 12895595. 
  • Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). „Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.”. Allergology international : official journal of the Japanese Society of Allergology 55 (2): 91–7. DOI:10.2332/allergolint.55.91. PMID 17075244. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags.”. Genome Res. 6 (9): 807–28. DOI:10.1101/gr.6.9.807. PMID 8889549. 
  • Yokomizo T, Izumi T, Chang K, et al. (1997). „A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.”. Nature 387 (6633): 620–4. DOI:10.1038/42506. PMID 9177352. 
  • Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 237 (2): 297–302. DOI:10.1006/bbrc.1997.7135. PMID 9268704. 
  • Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). „Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.”. Biochem. J. 335 (1): 15–8. PMC 1219746. PMID 9742207. 
  • Kato K, Yokomizo T, Izumi T, Shimizu T (2000). „Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.”. J. Exp. Med. 192 (3): 413–20. DOI:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229. 
  • Yokomizo T, Kato K, Terawaki K, et al. (2000). „A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.”. J. Exp. Med. 192 (3): 421–32. DOI:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230. 
  • Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). „Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.”. J. Immunol. 168 (7): 3570–6. PMID 11907121. 
  • Gaudreau R, Le Gouill C, Venne MH, et al. (2002). „Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.”. J. Biol. Chem. 277 (35): 31567–76. DOI:10.1074/jbc.M202723200. PMID 12077128. 
  • Hennig R, Ding XZ, Tong WG, et al. (2002). „5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.”. Am. J. Pathol. 161 (2): 421–8. DOI:10.1016/S0002-9440(10)64198-3. PMC 1850753. PMID 12163367. 
  • Ito N, Yokomizo T, Sasaki T, et al. (2003). „Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.”. J. Biol. Chem. 277 (47): 44898–904. DOI:10.1074/jbc.M208051200. PMID 12244116. 
  • Tong WG, Ding XZ, Hennig R, et al. (2003). „Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.”. Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). „In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor.”. Adv. Exp. Med. Biol. 507: 357–61. PMID 12664610. 

Vidi još

Spoljašnje veze

  • „Leukotriene Receptors: BLT1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2013-03-14. 
  • MeSH LTB4R+protein,+human
  • MeSH Receptors,+Leukotriene+B4
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)