Sekretinski receptor

edit
Sekretinski receptor
Identifikatori
SimboliSCTR; SR
Vanjski IDOMIM: 182098 HomoloGene: 68290 IUPHAR: secretin GeneCards: SCTR Gene
Ontologija gena
Molekularna funkcija • receptorska aktivnost
• aktivnost G-protein spregnutog receptora
• aktivnost vazoaktivnog intestinalnog polipeptidnog receptora
• aktivnost sekretinskog receptora
Celularna komponenta • integralno sa membranom plazme
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• varenje
• izlučivanje
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez6344n/a
EnsemblENSG00000080293n/a
UniProtP47872n/a
RefSeq (mRNA)NM_002980n/a
RefSeq (protein)NP_002971n/a
Lokacija (UCSC)Chr 2:
119.91 - 120 Mb		n/a
PubMed pretraga[1]n/a

Sekretinski receptor (ime gena SCTR) je G protein-spregnuti receptor koji vezuje sekretin, i koji je vodeći ćlan (i.e., prvo-klonirani) iz GPCR klase B potfamilije.[1]

Interakcije

Za sekretinski receptor je bilo pokazano da interaguje sa pituitarnim adenilat-ciklaza aktivirajućim peptidom.[2]

Literatura

  1. ↑ Dong M, Miller LJ (2002). „Molecular pharmacology of the secretin receptor”. Recept. Channels 8 (3-4): 189–200. DOI:10.1080/10606820213686. PMID 12529936. 
  2. ↑ Felley, C P; Qian J M, Mantey S, Pradhan T, Jensen R T (December 1992). „Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release”. Am. J. Physiol. (UNITED STATES) 263 (6 Pt 1): G901–7. ISSN 0002-9513. PMID 1335692. 

Dodatna literatura

  • Ulrich CD, Holtmann M, Miller LJ (1998). „Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors.”. Gastroenterology 114 (2): 382–97. DOI:10.1016/S0016-5085(98)70491-3. PMID 9453500. 
  • Felley CP, Qian JM, Mantey S, et al. (1993). „Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.”. Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692. 
  • Ishihara T, Nakamura S, Kaziro Y, et al. (1991). „Molecular cloning and expression of a cDNA encoding the secretin receptor.”. EMBO J. 10 (7): 1635–41. PMC 452832. PMID 1646711. 
  • Robberecht P, De Neef P, Waelbroeck M, et al. (1988). „Secretin receptors in human pancreatic membranes.”. Pancreas 3 (5): 529–35. DOI:10.1097/00006676-198810000-00004. PMID 3186683. 
  • Chow BK (1995). „Molecular cloning and functional characterization of a human secretin receptor.”. Biochem. Biophys. Res. Commun. 212 (1): 204–11. DOI:10.1006/bbrc.1995.1957. PMID 7612008. 
  • Patel DR, Kong Y, Sreedharan SP (1995). „Molecular cloning and expression of a human secretin receptor.”. Mol. Pharmacol. 47 (3): 467–73. PMID 7700244. 
  • Holtmann MH, Hadac EM, Miller LJ (1995). „Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors.”. J. Biol. Chem. 270 (24): 14394–8. DOI:10.1074/jbc.270.24.14394. PMID 7782300. 
  • Jiang S, Ulrich C (1995). „Molecular cloning and functional expression of a human pancreatic secretin receptor.”. Biochem. Biophys. Res. Commun. 207 (3): 883–90. DOI:10.1006/bbrc.1995.1268. PMID 7864894. 
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). „Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.”. Biochem. Biophys. Res. Commun. 193 (2): 546–53. DOI:10.1006/bbrc.1993.1658. PMID 8390245. 
  • Mark HF, Chow BK (1996). „Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry.”. Genomics 29 (3): 817–8. DOI:10.1006/geno.1995.9922. PMID 8575789. 
  • Vilardaga JP, di Paolo E, de Neef P, et al. (1996). „Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.”. Biochem. Biophys. Res. Commun. 218 (3): 842–6. DOI:10.1006/bbrc.1996.0150. PMID 8579602. 
  • Chow BK (1998). „Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor.”. Receptors & signal transduction 7 (3): 143–50. PMID 9440501. 
  • Shetzline MA, Premont RT, Walker JK, et al. (1998). „A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.”. J. Biol. Chem. 273 (12): 6756–62. DOI:10.1074/jbc.273.12.6756. PMID 9506976. 
  • Ho PK, Fong RS, Kai HS, et al. (1999). „The human secretin receptor gene: genomic organization and promoter characterization.”. FEBS Lett. 455 (3): 209–14. DOI:10.1016/S0014-5793(99)00864-9. PMID 10437774. 
  • Pang RT, Ng SS, Cheng CH, et al. (1999). „Role of N-linked glycosylation on the function and expression of the human secretin receptor.”. Endocrinology 140 (11): 5102–11. DOI:10.1210/en.140.11.5102. PMID 10537138. 
  • Chan KY, Pang RT, Chow BK (2001). „Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.”. Endocrinology 142 (9): 3926–34. DOI:10.1210/en.142.9.3926. PMID 11517171. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Pang RT, Lee LT, Ng SS, et al. (2004). „CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.”. Mol. Endocrinol. 18 (2): 471–83. DOI:10.1210/me.2003-0245. PMID 14645499. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 

Spoljašnje veze

  • IUPHAR GPCR baza podataka - Sekretinski receptor Arhivirano 2016-03-03 na Wayback Machine-u
  • MeSH secretin+receptor
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)