GPR103

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Proglutamilisani RF amid peptidni receptor
Identifikatori
SimboliQRFPR; GPR103 ; AQ27; MGC149217; SP9155
Vanjski IDOMIM: 606925 MGI: 2677633 HomoloGene: 18865 IUPHAR: QRFP GeneCards: QRFPR Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
• aktivnost neuropeptidnog Y receptora
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signal
• signalni put G-protein spregnutog receptora
Ortolozi
VrstaČovekMiš
Entrez84109229214
EnsemblENSG00000186867ENSMUSG00000058400
UniProtQ96P65Q3UQ27
RefSeq (mRNA)NM_198179NM_198192
RefSeq (protein)NP_937822NP_937835
Lokacija (UCSC)Chr 4:
122.47 - 122.52 Mb		Chr 3:
36.37 - 36.41 Mb
PubMed pretraga[1][2]

GPR103 (G protein-spregnuti receptor 103, piroglutamilisani RF amid peptidni receptor, oreksigenski neuropeptidni QRFP receptor) je protein koji je kod čoveka kodiran QRFPR genom.[1][2]

Funkcija

G protein spregnuti receptori sadrže sedam transmembranskih domena i prenose ekstracelularne signale putem heterotrimernih G proteina.[1]

P518, RF-amidni peptid sa 26 aminokiselina, funkcioniše kao ligand visokog afiniteta za GPR103 receptor. iRNK prekursori GPR103 i P518 proteina su visoko izraženi u mozgu.[3] QRFP peptid sa 43 aminokiselina, što je duži oblik P518 peptida, je neophodan za punu agonističku aktivnosti GPR103 receptora. Intravenozna administracija QRFP peptida uzrokuje oslobađanje aldosterona, iz čega proizilazi da QRFP i GPR103 regulišu adrenalnu funkciju.[4]

Literatura

  1. ↑ 1,0 1,1 „Entrez Gene: GPR103 G protein-coupled receptor 103”. 
  2. ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). „Discovery and mapping of ten novel G protein-coupled receptor genes”. Gene 275 (1): 83–91. DOI:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  3. ↑ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). „Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155”. J. Biol. Chem. 278 (30): 27652–7. DOI:10.1074/jbc.M302945200. PMID 12714592. 
  4. ↑ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). „A new peptidic ligand and its receptor regulating adrenal function in rats”. J. Biol. Chem. 278 (47): 46387–95. DOI:10.1074/jbc.M305270200. PMID 12960173. 

Dodatna literatura

  • Lee DK, Nguyen T, Lynch KR, et al. (2001). „Discovery and mapping of ten novel G protein-coupled receptor genes.”. Gene 275 (1): 83–91. DOI:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Jiang Y, Luo L, Gustafson EL, et al. (2003). „Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.”. J. Biol. Chem. 278 (30): 27652–7. DOI:10.1074/jbc.M302945200. PMID 12714592. 
  • Fukusumi S, Yoshida H, Fujii R, et al. (2004). „A new peptidic ligand and its receptor regulating adrenal function in rats.”. J. Biol. Chem. 278 (47): 46387–95. DOI:10.1074/jbc.M305270200. PMID 12960173. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
  • Takayasu S, Sakurai T, Iwasaki S, et al. (2006). „A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.”. Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7438–43. DOI:10.1073/pnas.0602371103. PMID 16648250. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)