SYT13

Protein-coding gene in the species Homo sapiens
SYT13
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WFM

Identifiers
AliasesSYT13, synaptotagmin 13
External IDsOMIM: 607716; MGI: 1933945; HomoloGene: 10823; GeneCards: SYT13; OMA:SYT13 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SYT13
Genomic location for SYT13
Band11p11.2Start45,240,302 bp[1]
End45,286,341 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SYT13
Genomic location for SYT13
Band2|2 E1Start92,745,443 bp[2]
End92,786,403 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 23

  • endothelial cell

  • islet of Langerhans

  • pons

  • superior frontal gyrus

  • postcentral gyrus

  • entorhinal cortex

  • prefrontal cortex

  • dorsolateral prefrontal cortex
Top expressed in
  • islet of Langerhans

  • medial dorsal nucleus

  • habenula

  • visual cortex

  • dorsomedial hypothalamic nucleus

  • medial geniculate nucleus

  • ventral tegmental area

  • piriform cortex

  • superior frontal gyrus

  • primary motor cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium-dependent phospholipid binding
  • clathrin binding
  • calcium ion binding
  • syntaxin binding
  • SNARE binding
  • phosphatidylserine binding
Cellular component
  • integral component of membrane
  • integral component of plasma membrane
  • transport vesicle
  • intracellular membrane-bounded organelle
  • membrane
  • plasma membrane
  • presynapse
  • synapse
  • exocytic vesicle
Biological process
  • vesicle-mediated transport
  • vesicle fusion
  • regulation of calcium ion-dependent exocytosis
  • calcium ion-regulated exocytosis of neurotransmitter
  • regulation of dopamine secretion
  • synaptic vesicle exocytosis
  • calcium-ion regulated exocytosis
  • cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57586

80976

Ensembl

ENSG00000019505

ENSMUSG00000027220

UniProt

Q7L8C5

Q9EQT6

RefSeq (mRNA)

NM_020826
NM_001247987

NM_030725

RefSeq (protein)

NP_001234916
NP_065877

NP_109650

Location (UCSC)Chr 11: 45.24 – 45.29 MbChr 2: 92.75 – 92.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.[5][6]

Function

SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins show type I membrane topology, with an extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include vesicular traffic, exocytosis, and secretion.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000019505 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027220 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fukuda M, Mikoshiba K (March 2001). "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)". The Biochemical Journal. 354 (Pt 2): 249–57. doi:10.1042/0264-6021:3540249. PMC 1221650. PMID 11171101.
  6. ^ a b "Entrez Gene: SYT13 synaptotagmin XIII".

Further reading

  • Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q7L8C5 (Human Synaptotagmin-13 (SYT13)) at the PDBe-KB.
  • v
  • t
  • e
  • 1wfm: The first C2 domain of human synaptotagmin XIII
    1wfm: The first C2 domain of human synaptotagmin XIII
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPI
COPII
RME/Clathrin
Caveolae
Other/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders
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