EHD2

Protein-coding gene in the species Homo sapiens
EHD2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2QPT, 4CID

Identifiers
AliasesEHD2, PAST2, EH domain containing 2
External IDsOMIM: 605890; MGI: 2154274; HomoloGene: 22825; GeneCards: EHD2; OMA:EHD2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for EHD2
Genomic location for EHD2
Band19q13.33Start47,713,422 bp[1]
End47,743,134 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for EHD2
Genomic location for EHD2
Band7 A2|7 8.65 cMStart15,680,883 bp[2]
End15,701,492 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • right coronary artery

  • popliteal artery

  • subcutaneous adipose tissue

  • left coronary artery

  • ascending aorta

  • right lung

  • canal of the cervix

  • gastric mucosa

  • left uterine tube
Top expressed in
  • ascending aorta

  • aortic valve

  • brown adipose tissue

  • left lung

  • right lung

  • left lung lobe

  • right lung lobe

  • ankle

  • subcutaneous adipose tissue

  • white adipose tissue
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • protein domain specific binding
  • nucleotide binding
  • calcium ion binding
  • GTP binding
  • hydrolase activity
  • ATP binding
  • nucleic acid binding
  • identical protein binding
Cellular component
  • caveola
  • endosome membrane
  • recycling endosome membrane
  • cytoplasm
  • cytosol
  • nucleus
  • membrane
  • perinuclear region of cytoplasm
  • endosome
  • extrinsic component of membrane
  • extracellular exosome
  • plasma membrane
  • microtubule cytoskeleton
  • intercellular bridge
Biological process
  • blood coagulation
  • endocytosis
  • protein localization to plasma membrane
  • plasma membrane tubulation
  • positive regulation of myoblast fusion
  • positive regulation of endocytic recycling
  • actin cytoskeleton organization
  • cortical actin cytoskeleton organization
  • endocytic recycling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30846

259300

Ensembl

ENSG00000024422

ENSMUSG00000074364

UniProt

Q9NZN4

Q8BH64

RefSeq (mRNA)

NM_014601

NM_153068

RefSeq (protein)

NP_055416

NP_694708

Location (UCSC)Chr 19: 47.71 – 47.74 MbChr 7: 15.68 – 15.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EH-domain containing 2, also known as EHD2, is a human gene[5] belonging to the EHD protein family.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000024422 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074364 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EHD2 EH-domain containing 2".

Further reading

  • Pohl U, Smith JS, Tachibana I, et al. (2000). "EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins". Genomics. 63 (2): 255–62. doi:10.1006/geno.1999.6087. PMID 10673336.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Guilherme A, Soriano NA, Bose S, et al. (2004). "EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton". J. Biol. Chem. 279 (11): 10593–605. doi:10.1074/jbc.M307702200. PMID 14676205.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Park SY, Ha BG, Choi GH, et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment". Biochemistry. 43 (23): 7552–62. doi:10.1021/bi049970f. PMID 15182197.
  • Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
  • Guilherme A, Soriano NA, Furcinitti PS, Czech MP (2004). "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes". J. Biol. Chem. 279 (38): 40062–75. doi:10.1074/jbc.M401918200. PMID 15247266.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q8BH64 (Mouse EH domain-containing protein 2 (EHD2)) at the PDBe-KB.


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