DNM3

Protein-coding gene in the species Homo sapiens
DNM3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3L43, 5A3F

Identifiers
AliasesDNM3, Dyna III, dynamin 3
External IDsOMIM: 611445; MGI: 1341299; HomoloGene: 22906; GeneCards: DNM3; OMA:DNM3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DNM3
Genomic location for DNM3
Band1q24.3Start171,817,887 bp[1]
End172,418,466 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DNM3
Genomic location for DNM3
Band1|1 H2.1Start161,810,022 bp[2]
End162,305,603 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • pons

  • Brodmann area 46

  • corpus callosum

  • Pars compacta

  • postcentral gyrus

  • superior vestibular nucleus

  • dorsal motor nucleus of vagus nerve

  • pars reticulata

  • orbitofrontal cortex
Top expressed in
  • facial motor nucleus

  • anterior horn of spinal cord

  • superior colliculus

  • inferior colliculus

  • pontine nuclei

  • medial vestibular nucleus

  • substantia nigra

  • dorsal tegmental nucleus

  • medial dorsal nucleus

  • ventral tegmental area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • nitric-oxide synthase binding
  • type 1 metabotropic glutamate receptor binding
  • GTP binding
  • type 5 metabotropic glutamate receptor binding
  • protein binding
  • hydrolase activity
  • GTPase activity
  • microtubule binding
  • identical protein binding
  • structural constituent of postsynapse
Cellular component
  • cytoplasm
  • Golgi apparatus
  • postsynaptic density
  • photoreceptor inner segment
  • dendritic spine
  • synapse
  • axon
  • dendritic spine head
  • mitochondrion
  • perinuclear region of cytoplasm
  • synaptic cleft
  • microtubule
  • extracellular exosome
  • cytoskeleton
  • mitochondrial membranes
  • postsynaptic endocytic zone membrane
  • plasma membrane
  • membrane
  • cytoplasmic vesicle
  • postsynaptic membrane
  • apical tubulobulbar complex
  • basal tubulobulbar complex
  • presynapse
  • glutamatergic synapse
Biological process
  • endocytosis
  • positive regulation of filopodium assembly
  • regulation of dendritic spine morphogenesis
  • negative regulation of dendritic spine morphogenesis
  • mitochondrial fission
  • dynamin family protein polymerization involved in mitochondrial fission
  • synapse assembly
  • filopodium assembly
  • membrane fusion
  • synaptic vesicle budding from presynaptic endocytic zone membrane
  • postsynaptic neurotransmitter receptor internalization
  • receptor internalization
  • synaptic vesicle endocytosis
  • regulation of synapse structure or activity
  • postsynapse organization
  • positive regulation of synaptic vesicle recycling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26052

103967

Ensembl

ENSG00000197959

ENSMUSG00000040265

UniProt

Q9UQ16

Q8BZ98

RefSeq (mRNA)
NM_001136127
NM_001278252
NM_015569
NM_001350204
NM_001350205

NM_001350206

NM_001038619
NM_172646

RefSeq (protein)
NP_001129599
NP_001265181
NP_056384
NP_001337133
NP_001337134

NP_001337135

NP_001033708
NP_766234

Location (UCSC)Chr 1: 171.82 – 172.42 MbChr 1: 161.81 – 162.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene.[5][6] The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.[7] DNM3 is upregulated in Sézary's syndrome.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197959 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040265 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. ^ "Entrez Gene: DNM3 dynamin 3".
  7. ^ Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
  8. ^ Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia. 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Sever S (2003). "Dynamin and endocytosis". Curr. Opin. Cell Biol. 14 (4): 463–7. doi:10.1016/S0955-0674(02)00347-2. PMID 12383797.
  • Wiejak J, Wyroba E (2003). "Dynamin: characteristics, mechanism of action and function". Cell. Mol. Biol. Lett. 7 (4): 1073–80. PMID 12511974.
  • Orth JD, McNiven MA (2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
  • Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
  • Larsen MR, Graham ME, Robinson PJ, Roepstorff P (2004). "Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III". Mol. Cell. Proteomics. 3 (5): 456–65. doi:10.1074/mcp.M300105-MCP200. PMID 14762214.
  • Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9UQ16 (Dynamin-3) at the PDBe-KB.


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Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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