CEP135

Protein-coding gene in the species Homo sapiens
CEP135
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5FCN

Identifiers
AliasesCEP135, CEP4, KIAA0635, MCPH8, centrosomal protein 135
External IDsOMIM: 611423; MGI: 2681869; HomoloGene: 45709; GeneCards: CEP135; OMA:CEP135 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CEP135
Genomic location for CEP135
Band4q12Start55,948,871 bp[1]
End56,033,361 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CEP135
Genomic location for CEP135
Band5|5 C3.3Start76,736,545 bp[2]
End76,794,313 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amniotic fluid

  • buccal mucosa cell

  • sperm

  • ventricular zone

  • testicle

  • gonad

  • bone marrow

  • monocyte

  • Achilles tendon

  • secondary oocyte
Top expressed in
  • zygote

  • genital tubercle

  • tail of embryo

  • secondary oocyte

  • spermatid

  • spermatocyte

  • granulocyte

  • ventricular zone

  • primary oocyte

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein C-terminus binding
  • protein binding
Cellular component
  • cytoplasm
  • centriole
  • cytosol
  • centrosome
  • cytoskeleton
Biological process
  • centriole replication
  • centriole-centriole cohesion
  • G2/M transition of mitotic cell cycle
  • positive regulation of non-motile cilium assembly
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
  • positive regulation of establishment of protein localization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9662

381644

Ensembl

ENSG00000174799

ENSMUSG00000036403

UniProt

Q66GS9

Q6P5D4

RefSeq (mRNA)

NM_014645
NM_025009

NM_199032

RefSeq (protein)

NP_079285

NP_950197

Location (UCSC)Chr 4: 55.95 – 56.03 MbChr 5: 76.74 – 76.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.[5][6][7] It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.[8] CEP135 is required for the centriolar localization of CEP250.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174799 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036403 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  7. ^ "Entrez Gene: CEP135 centrosomal protein 135kDa".
  8. ^ Ohta T, Essner R, Ryu JH, Palazzo RE, Uetake Y, Kuriyama R (January 2002). "Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells". J. Cell Biol. 156 (1): 87–99. doi:10.1083/jcb.200108088. PMC 2173569. PMID 11781336.
  9. ^ Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962.

External links

  • Human CEP135 genome location and CEP135 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 135 kDa

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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