CEP104

Protein-coding gene in the species Homo sapiens
CEP104
Identifiers
AliasesCEP104, GlyBP, KIAA0562, CFAP256, JBTS25, ROC22, centrosomal protein 104
External IDsOMIM: 616690; MGI: 2687282; HomoloGene: 44919; GeneCards: CEP104; OMA:CEP104 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CEP104
Genomic location for CEP104
Band1p36.32Start3,812,081 bp[1]
End3,857,214 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CEP104
Genomic location for CEP104
Band4|4 E2Start154,059,651 bp[2]
End154,093,189 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • buccal mucosa cell

  • sperm

  • internal globus pallidus

  • saphenous vein

  • inferior ganglion of vagus nerve

  • islet of Langerhans

  • lactiferous duct

  • sural nerve

  • stromal cell of endometrium
Top expressed in
  • olfactory epithelium

  • muscle of thigh

  • zygote

  • digastric muscle

  • triceps brachii muscle

  • temporal muscle

  • sternocleidomastoid muscle

  • skeletal muscle tissue

  • extraocular muscle

  • secondary oocyte
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

9731

230967

Ensembl

ENSG00000116198

ENSMUSG00000039523

UniProt

O60308

Q80V31

RefSeq (mRNA)

NM_014704

NM_177673

RefSeq (protein)

NP_055519

NP_808341

Location (UCSC)Chr 1: 3.81 – 3.86 MbChr 4: 154.06 – 154.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein 104kDa is a protein that in humans is encoded by the CEP104 gene. [5] Like its Chlamydomonas ortholog, FAP256, it has been shown to localize to the distal ends of both centrioles in the absence of a cilium. During cilium formation, it is found at the tip of the elongating cilium.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116198 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039523 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Centrosomal protein 104kDa". Retrieved 2014-06-04.
  6. ^ Satish Tammana TV, Tammana D, Diener DR, Rosenbaum J (November 2013). "Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assembly". Journal of Cell Science. 126 (Pt 21): 5018–29. doi:10.1242/jcs.133439. PMC 3820246. PMID 23970417.

External links

  • Human CEP104 genome location and CEP104 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: O60308 (Centrosomal protein of 104 kDa) at the PDBe-KB.

Further reading

  • Kumar KN, Babcock KK, Johnson PS, Chen X, Ahmad M, Michaelis EK (November 1995). "Cloning of the cDNA for a brain glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein". Biochemical and Biophysical Research Communications. 216 (1): 390–8. doi:10.1006/bbrc.1995.2636. PMID 7488117.
  • Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS (April 2011). "Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods". The EMBO Journal. 30 (8): 1520–35. doi:10.1038/emboj.2011.63. PMC 3102290. PMID 21399614.
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