Peramivir : Osobine, Reference, Literatura, Spoljašnje veze Википедија

Peramivir

Peramivir
Klinički podaci

Drugs.com	Monografija
Identifikatori
CAS broj	229614-55-5^Y
ATC kod	none
PubChem	CID 151164
ChemSpider	133234^Y
UNII	9ZS94HQO3B^Y
ChEMBL	CHEMBL332608^Y
Hemijski podaci
Formula	C₁₅H₂₈N₄O₄
Molarna masa	328,407
SMILES CCC(CC)C(\N=C(/C)\O)[C@@H]1[C@H](O)[C@H](C[C@H]1NC(=N)N)C(=O)O
InChI InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12?,13+/m0/s1^Y Key:XRQDFNLINLXZLB-GKWMMFDUSA-N^Y

Peramivir je organsko jedinjenje, koje sadrži 15 atoma ugljenika i ima molekulsku masu od 328,407 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	6
Broj donora vodonika	6
Broj rotacionih veza	8
Particioni koeficijent^[1] (ALogP)	0,6
Rastvorljivost^[2] (logS, log(mol/L))	-2,2
Polarna površina^[3] (PSA, Å²)	152,0

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.