BIRC3

Bakuloviralni protein 3 koji sadrži IAP ponavljanje

PDB prikaz baziran na 2uvl.

Dostupne strukture

2UVL, 3EB5, 3EB6, 3M0A, 3M0D

Identifikatori

Simboli

BIRC3; AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; c-IAP2

Vanjski ID

OMIM: 601721 MGI: 1197007 HomoloGene: 899 GeneCards: BIRC3 Gene

Ontologija gena
Molekularna funkcija	• aktivnost ligaze ubikvitinskog proteina • proteinsko vezivanje • vezivanje jona cinka
Celularna komponenta	• jedro • citoplazma
Biološki proces	• apoptotički proces • antiapoptoza • signalni put receptora na ćelijskoj površini • regulacija signalnog puta tol-sličnog receptora • NIK/NF-kapaB kaskada • regulacija RIG-I signalnog puta

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

330

11796

Ensembl

ENSG00000023445

ENSMUSG00000032000

UniProt

Q13489

O08863

RefSeq (mRNA)

NM_001165.4

NM_007464.3

RefSeq (protein)

NP_001156.1

NP_031490.2

Lokacija (UCSC)

Chr 11:
102.19 - 102.21 Mb

Chr 9:
7.85 - 7.87 Mb

PubMed pretraga

[1]

[2]

Bakulovirusni protein 3 koji sadrži IAP ponavljanje (cIAP2) je protein koji je kod ljudi kodiran BIRC3 genom.^[1]^[2]

cIAP2 je član familije Inhibitora apoptoze koja inhibira apoptozu putem ometanja aktivacije kaspaze. Ovaj pretein inhibra apoptozu indukovanu serumskom deprivacijom, ali nema uticaja na apoptozu koja proizilazi iz izlaganja menadionu, potentnom induktoru slobodnih radikala. cIAP2 protein sadrži tri BIR domensa UBA domen, CARD domen i RING prst domen. Poznato je nekoliko transkriptnih varijanti ovog proteina.^[3]

Interakcije

Bakulovirusni protein 3 koji sadrži IAP ponavljanje formira interakcije sa TRAF1,^[4]^[5] TRAF2,^[4]^[5]^[6]^[7] RIPK1,^[8] kaspazom-9^[9] i UBE2D2.^[10]

Reference

^ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature. 379 (6563): 349—53. PMID 8552191. doi:10.1038/379349a0.
^ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins”. Cell. 83 (7): 1243—52. PMID 8548810. doi:10.1016/0092-8674(95)90149-3.
^ „Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3”.
^ ^а ^б Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. ENGLAND. 16 (23): 6914—25. ISSN 0261-4189. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
^ ^а ^б Li X, Yang Y, Ashwell JD (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature. England. 416 (6878): 345—7. ISSN 0028-0836. PMID 11907583. doi:10.1038/416345a.
^ Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (10): 4974—8. ISSN 0027-8424. PMC 39390 . PMID 8643514. doi:10.1073/pnas.93.10.4974.
^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. UNITED STATES. 275 (15): 11114—20. ISSN 0021-9258. PMID 10753917. doi:10.1074/jbc.275.15.11114.
^ Bertrand, Mathieu J M; Milutinovic Snezana; et al. (2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell. United States. 30 (6): 689—700. PMID 18570872. doi:10.1016/j.molcel.2008.05.014.
^ Deveraux, Q L; Roy N; et al. (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. ENGLAND. 17 (8): 2215—23. ISSN 0261-4189. PMC 1170566 . PMID 9545235. doi:10.1093/emboj/17.8.2215.
^ Mace, Peter D; Linke Katrin; et al. (2008). „Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment”. J. Biol. Chem. United States. 283 (46): 31633—40. ISSN 0021-9258. PMID 18784070. doi:10.1074/jbc.M804753200.

Literatura

Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). „Genetic alterations underlying the pathogenesis of MALT lymphoma”. Hematol. J. 3 (1): 10—3. PMID 11960389. doi:10.1038/sj/thj/6200146.
Uren AG; Pakusch M; Hawkins CJ; et al. (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974—8. PMC 39390 . PMID 8643514. doi:10.1073/pnas.93.10.4974.
Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). „Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization”. Genomics. 37 (3): 404—6. PMID 8938457. doi:10.1006/geno.1996.0579.
Roy N; Deveraux QL; Takahashi R; et al. (1998). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. 16 (23): 6914—25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
Deveraux QL; Roy N; Stennicke HR; et al. (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. 17 (8): 2215—23. PMC 1170566 . PMID 9545235. doi:10.1093/emboj/17.8.2215.
Young SS, Liston P, Xuan JY, et al. (1999). „Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2”. Mamm. Genome. 10 (1): 44—8. PMID 9892732. doi:10.1007/s003359900940.
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Li X, Yang Y, Ashwell JD (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature. 416 (6878): 345—7. PMID 11907583. doi:10.1038/416345a.
Gordon GJ; Appasani K; Parcells JP; et al. (2002). „Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma”. Carcinogenesis. 23 (6): 1017—24. PMID 12082024. doi:10.1093/carcin/23.6.1017.
Sharief MK, Noori MA, Zoukos Y (2002). „Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy”. J. Neuroimmunol. 129 (1–2): 224—31. PMID 12161039. doi:10.1016/S0165-5728(02)00185-6.
Ekedahl J; Joseph B; Grigoriev MY; et al. (2002). „Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells”. Exp. Cell Res. 279 (2): 277—90. PMID 12243753. doi:10.1006/excr.2002.5608.