PFKL

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Fosfofruktokinaza, jetra
Identifikatori
SimboliPFKL; ATP-PFK; PFK-B; PFK-L
Vanjski IDOMIM: 171860 MGI: 97547 HomoloGene: 55668 GeneCards: PFKL Gene
EC broj2.7.1.11
Ontologija gena
Molekulska funkcija • 6-fosfofruktokinazna aktivnost
• proteinsko vezivanje
• ATP vezivanje
Ćelijska komponenta • citosol
• 6-fosfofruktokinazni kompleks
• membrana
Biološki proces • ugljenohidratni metabolički proces
• fruktoza 6-fosfatni metabolički proces
• glukozni metabolički proces
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez521118641
EnsemblENSG00000141959ENSMUSG00000020277
UniProtP17858P12382
Ref. Sekv. (iRNK)NM_001002021NM_008826
Ref. Sekv. (protein)NP_001002021NP_032852
Lokacija (UCSC)Chr 21:
45.72 - 45.75 Mb		Chr 10:
77.99 - 78.01 Mb
PubMed pretraga[1][2]

6-Fosfofruktokinaza, jetreni tip je enzim koji je kod ljudi kodiran PFKL genom.[1]

Fosfofruktokinaza (PFK) je tetramerni enzim koji katalizuje ključni korak u glikolizi, konverziju D-fruktoze 6-fosfata do D-fruktoze 1,6-bisfosfata. Zasebni genei kodiraju mišićnu podjedinicu (M) i jetrenu podjedinicu (L). PFK iz mišića je homotetramer M podjedinica, PFK iz jetre je homotetramer L-jedinica, dok se PFK iz trombocita može sastojati od bilo koje tetramerne kombinacije M i L podjedinica. Protein kodiran ovim genom je L podjedinica. Dve transkriptne varijante koje kodiraju različite izoforme su poznate.[1]

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: PFKL phosphofructokinase, liver”. 

Literatura

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Transferaze: fosfor-sadržavajuće grupe (EC 2.7)
2.7.1-2.7.4:
fosfotransferaze/kinaze
(PO4)
2.7.1: OH- akceptor
2.7.2: COOH akceptor
2.7.3: N akceptor
2.7.4: PO4 akceptor
2.7.6: difosfotransferaze
(P2O7)2.7.7: nukleotidiltransferaza
(PO4-nukleozid)
RNK nukleotidiltransferaza
Druge
2.7.8: razno
Fosfatidiltransferaze
Glikozil-1-fosfotransferaza
2.7.10-2.7.13: proteinske kinaze
(PO4; proteinski akceptor)
vidi serin/treonin-specifične proteinske kinaze
2.7.12: dualna specifičnost
vidi serin/treonin-specifične proteinske kinaze
2.7.13: protein-histidinske
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6