Arahidonat 5-lipoksigenaza
| Arachidonat 5-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.34 | ||||||||
| CAS broj | 80619-02-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Arahidonat 5-lipoksigenaza (EC 1.13.11.34, leukotrien-A4 sintaza, Delta5-lipoksigenaza, 5Delta-lipoksigenaza, arahidonska 5-lipoksigenaza, arahidonska kiselina 5-lipoksigenaza, C-5-lipoksigenaza, LTA sintaza, leukotrienska A4 sintaza) je enzim sa sistematskim imenom arachidonat:kiseonik 5-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- arahidonat + O2 leukotrien A4 + H2O (sveukupna reakcija)
- (1a) arahidonat + O2 (6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat
- (1b) (6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat leukotrien A4 +H2O
Reference
- ↑ Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. (1988). „Molecular cloning and amino acid sequence of human 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 85: 26-30. PMID 2829172.
- ↑ Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers”. J. Biol. Chem. 262: 10200-10205. PMID 3038871.
- ↑ Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B. (1986). „Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 83: 4175-4179. PMID 3012557.
- ↑ Shimizu, T., Rädmark, O. and Samuelssohn, B. (1984). „Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid”. Proc. Natl. Acad. Sci. USA 81: 689-693. PMID 6322165.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Vanjske veze
- MeSH Arachidonate+5-lipoxygenase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
