Vorsetuzumab mafodotin
Chemical compound
- none
- Discontinued
- 1165741-01-4 Y
- none
- 699619YVTQ
- D10341
Vorsetuzumab mafodotin (SGN-75) is an antibody-drug conjugate (ADC) directed to the protein CD70 designed for the treatment of cancer.[1] It is a humanized monoclonal antibody, vorsetuzumab, conjugated with noncleavable monomethyl auristatin F (MMAF), a cytotoxic agent.[citation needed]
This drug was developed by Seattle Genetics, Inc. The drug completed phase I clinical trials for renal cell carcinoma,[2] but development was discontinued in 2013.[3] No reason was given but SG plan to start clinical trials of SGN-CD70A in 2014.[3]
References
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Monoclonal antibodies for tumors
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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