SRD5A3

Protein-coding gene in the species Homo sapiens
SRD5A3
Identifiers
AliasesSRD5A3, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3
External IDsOMIM: 611715 MGI: 1930252 HomoloGene: 41385 GeneCards: SRD5A3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SRD5A3
Genomic location for SRD5A3
Band4q12Start55,346,213 bp[1]
End55,373,100 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SRD5A3
Genomic location for SRD5A3
Band5|5 C3.3Start76,288,118 bp[2]
End76,303,351 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • palpebral conjunctiva

  • gallbladder

  • body of pancreas

  • islet of Langerhans

  • stromal cell of endometrium

  • minor salivary glands

  • left adrenal gland

  • right adrenal gland

  • skin of abdomen

  • prefrontal cortex
Top expressed in
  • secondary oocyte

  • internal carotid artery

  • yolk sac

  • lip

  • external carotid artery

  • condyle

  • ascending aorta

  • proximal tubule

  • sciatic nerve

  • aortic valve
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • oxidoreductase activity, acting on the CH-CH group of donors
  • cholestenone 5-alpha-reductase activity
  • oxidoreductase activity
  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity
  • oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
  • polyprenol reductase activity
Cellular component
  • cytoplasm
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • endoplasmic reticulum
Biological process
  • lipid metabolism
  • polyprenol catabolic process
  • androgen biosynthetic process
  • protein glycosylation
  • dolichol metabolic process
  • dolichyl diphosphate biosynthetic process
  • dolichol-linked oligosaccharide biosynthetic process
  • dolichol biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79644

57357

Ensembl

ENSG00000128039

ENSMUSG00000029233

UniProt

Q9H8P0

Q9WUP4

RefSeq (mRNA)

NM_024592

NM_020611

RefSeq (protein)

NP_078868

NP_065636

Location (UCSC)Chr 4: 55.35 – 55.37 MbChr 5: 76.29 – 76.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.[5][6] It is one of three forms of 5α-reductase.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128039 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029233 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: steroid 5 alpha-reductase 3".
  6. ^ Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Sci. 99 (1): 81–6. doi:10.1111/j.1349-7006.2007.00656.x. PMID 17986282. S2CID 51733620.

Further reading

  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocr. Rev. 25 (6): 947–70. doi:10.1210/er.2003-0030. PMID 15583024.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cantagrel V, Lefeber DJ, Ng BG, et al. (2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–17. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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1.3.1: NAD/NADP acceptor1.3.3: Oxygen acceptor1.3.5: Quinone1.3.99: Other acceptors
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