Proquazone
Nonsteroidal anti-inflammatory drug
- M01AX13 (WHO)
- 1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one
- 22760-18-5 N
- 31508
- 29222 N
- 42VPJ2980S
- ChEMBL268501 N
- DTXSID4021210
- Interactive image
- CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
InChI
- InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 N
- Key:JTIGKVIOEQASGT-UHFFFAOYSA-N N
Proquazone is a nonsteroidal anti-inflammatory drug, known as an NSAID.[1]
Uses
Proquazone is used to treat rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.[1] It has been trialed for use as pain relief for tension headaches.[2]
The recommended adult dose is around 450mg.[1]
Side Effects
Often, use of Proquazone is associated with diarrhea (up to 30% of the time).[1]
References
- ^ a b c d Clissold SP, Beresford R (May 1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states". Drugs. 33 (5): 478–502. doi:10.2165/00003495-198733050-00004. PMID 3297621. S2CID 195697106.
- ^ DiSerio FJ, Friedman AP, Parno J, Singer JM (May 1985). "Proquazone for tension headache--a multicenter trial". Headache. 25 (3): 127–133. doi:10.1111/j.1526-4610.1985.hed2503127.x. PMID 3891682. S2CID 9283866.
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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