NINJ1

Protein-coding gene in the species Homo sapiens
NINJ1
Identifiers
AliasesNINJ1, NIN1, NINJURIN, ninjurin 1
External IDsOMIM: 602062; MGI: 1196617; HomoloGene: 88815; GeneCards: NINJ1; OMA:NINJ1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NINJ1
Genomic location for NINJ1
Band9q22.31Start93,121,496 bp[1]
End93,134,251 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for NINJ1
Genomic location for NINJ1
Band13|13 A5Start49,340,961 bp[2]
End49,349,720 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • monocyte

  • thoracic aorta

  • ascending aorta

  • Descending thoracic aorta

  • right lobe of liver

  • blood

  • gastric mucosa
Top expressed in
  • stroma of bone marrow

  • pyloric antrum

  • right kidney

  • left lobe of liver

  • facial motor nucleus

  • calvaria

  • utricle

  • tibiofemoral joint

  • vestibular sensory epithelium

  • primary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • membrane
Biological process
  • hyaloid vascular plexus regression
  • cell adhesion
  • nervous system development
  • tissue regeneration
  • positive regulation of cell-matrix adhesion
  • pyroptosis
  • cell death
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4814

18081

Ensembl

ENSG00000131669

ENSMUSG00000037966

UniProt

Q92982

O70131

RefSeq (mRNA)

NM_004148

NM_013610

RefSeq (protein)

NP_004139

NP_038638

Location (UCSC)Chr 9: 93.12 – 93.13 MbChr 13: 49.34 – 49.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ninjurin-1 is a protein that in humans is encoded by the NINJ1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131669 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037966 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Araki T, Milbrandt J (Oct 1996). "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth". Neuron. 17 (2): 353–61. doi:10.1016/S0896-6273(00)80166-X. PMID 8780658. S2CID 12471778.
  6. ^ "Entrez Gene: NINJ1 ninjurin 1".

Further reading

  • Guimarães PE, Fridman C, Gregório SP, et al. (2007). "WITHDRAWN: Association between polymorphisms in genes of inflammatory response and axonal repair with spinal cord injury". Spinal Cord. doi:10.1038/sj.sc.3102122. PMID 17893696.
  • Cardoso CC, Martinez AN, Guimarães PE, et al. (2007). "Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage". J. Neuroimmunol. 190 (1–2): 131–8. doi:10.1016/j.jneuroim.2007.07.015. PMID 17825431. S2CID 20637695.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Toyama T, Sasaki Y, Horimoto M, et al. (2005). "Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells". J. Hepatol. 41 (4): 637–43. doi:10.1016/j.jhep.2004.06.027. PMID 15464245.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chadwick BP, Heath SK, Williamson J, et al. (1998). "The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI)". Genomics. 47 (1): 58–63. doi:10.1006/geno.1997.5084. PMID 9465296.
  • Araki T, Zimonjic DB, Popescu NC, Milbrandt J (1997). "Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule". J. Biol. Chem. 272 (34): 21373–80. doi:10.1074/jbc.272.34.21373. PMID 9261151.


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