LCOR

Protein-coding gene in the species Homo sapiens
LCOR
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2COB

Identifiers
AliasesLCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDsOMIM: 607698; MGI: 2443930; HomoloGene: 22914; GeneCards: LCOR; OMA:LCOR - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for LCOR
Genomic location for LCOR
Band10q24.1Start96,832,254 bp[1]
End96,995,956 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for LCOR
Genomic location for LCOR
Band19|19 C3Start41,471,076 bp[2]
End41,574,975 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • jejunal mucosa

  • mucosa of paranasal sinus

  • mucosa of ileum

  • visceral pleura

  • cardia

  • pylorus

  • renal medulla

  • nipple

  • mucosa of sigmoid colon
Top expressed in
  • epithelium of stomach

  • ventromedial nucleus

  • migratory enteric neural crest cell

  • Rostral migratory stream

  • ciliary body

  • lateral septal nucleus

  • mammillary body

  • human fetus

  • retinal pigment epithelium

  • left colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity
  • transcription factor binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • negative regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84458

212391

Ensembl

ENSG00000196233

ENSMUSG00000025019

UniProt

Q96JN0

Q6ZPI3

RefSeq (mRNA)

NM_001170765
NM_001170766
NM_001346516
NM_015652
NM_032440

NM_172154
NM_001370767

RefSeq (protein)

NP_001164236
NP_001164237
NP_001333445
NP_115816

NP_742166
NP_001357696

Location (UCSC)Chr 10: 96.83 – 97 MbChr 19: 41.47 – 41.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.[5][6][7]

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196233 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025019 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528.
  6. ^ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 978-0-12-709868-5. PMID 15193453.
  7. ^ a b "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

Further reading

  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/S0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
  • Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. Bibcode:2003Natur.422..735S. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor


  • v
  • t
  • e
  • 2cob: Solution structures of the HTH domain of human LCoR protein
    2cob: Solution structures of the HTH domain of human LCoR protein
  • v
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  • e
Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF


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