EID1

Protein-coding gene in the species Homo sapiens
EID1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4NUF

Identifiers
AliasesEID1, C15orf3, CRI1, EID-1, IRO45620, PTD014, RBP21, PNAS-22, EP300 interacting inhibitor of differentiation 1
External IDsOMIM: 605894; MGI: 1889651; HomoloGene: 49376; GeneCards: EID1; OMA:EID1 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for EID1
Genomic location for EID1
Band15q21.1Start48,878,134 bp[1]
End48,880,173 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for EID1
Genomic location for EID1
Band2|2 F1Start125,515,015 bp[2]
End125,516,705 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • Achilles tendon

  • germinal epithelium

  • right ventricle

  • internal globus pallidus

  • seminal vesicula

  • superficial temporal artery

  • ganglionic eminence

  • retinal pigment epithelium

  • myocardium
Top expressed in
  • barrel cortex

  • dorsomedial hypothalamic nucleus

  • Gonadal ridge

  • median eminence

  • human fetus

  • fossa

  • atrium

  • habenula

  • condyle

  • subiculum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • histone acetyltransferase binding
  • transcription corepressor activity
  • histone acetyltransferase regulator activity
Cellular component
  • cytoplasm
  • nucleus
  • nucleoplasm
  • cytoplasmic ribonucleoprotein granule
Biological process
  • cell cycle
  • cell differentiation
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • regulation of histone acetylation
  • regulation of cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23741

58521

Ensembl

ENSG00000255302

ENSMUSG00000091337

UniProt

Q9Y6B2

Q9DCR4

RefSeq (mRNA)

NM_014335

NM_025613

RefSeq (protein)

NP_055150

NP_079889

Location (UCSC)Chr 15: 48.88 – 48.88 MbChr 2: 125.52 – 125.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene.[5][6][7]

Interactions

EID1 has been shown to interact with EP300[6][8] and Retinoblastoma protein.[6][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255302 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091337 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (June 2000). "Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2". Cytogenet Cell Genet. 88 (3–4): 330–2. doi:10.1159/000015523. PMID 10828624. S2CID 27139235.
  6. ^ a b c MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). "A novel Rb- and p300-binding protein inhibits transactivation by MyoD". Mol Cell Biol. 20 (23): 8903–15. doi:10.1128/MCB.20.23.8903-8915.2000. PMC 86545. PMID 11073990.
  7. ^ "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1".
  8. ^ a b Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G (December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. ISSN 0270-7306. PMC 86544. PMID 11073989.

Further reading

  • Ghosh AK, Varga J (2007). "The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis". J. Cell. Physiol. 213 (3): 663–71. doi:10.1002/jcp.21162. PMID 17559085. S2CID 41744258.
  • Margottin F, Bour SP, Durand H, et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif". Mol. Cell. 1 (4): 565–74. doi:10.1016/S1097-2765(00)80056-8. PMID 9660940.
  • Miyake S, Sellers WR, Safran M, et al. (2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. PMC 86544. PMID 11073989.
  • Wen H, Ao S (2001). "Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein". Gene. 263 (1–2): 85–92. doi:10.1016/S0378-1119(00)00585-0. PMID 11223246.
  • Båvner A, Johansson L, Toresson G, et al. (2002). "A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP". EMBO Rep. 3 (5): 478–84. doi:10.1093/embo-reports/kvf087. PMC 1084100. PMID 11964378.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ledl A, Schmidt D, Müller S (2005). "Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor". Oncogene. 24 (23): 3810–8. doi:10.1038/sj.onc.1208539. PMID 15806172.
  • Krützfeldt M, Ellis M, Weekes DB, et al. (2005). "Selective ablation of retinoblastoma protein function by the RET finger protein". Mol. Cell. 18 (2): 213–24. doi:10.1016/j.molcel.2005.03.009. PMID 15837424.
  • Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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