Carboxyamidotriazole
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Preferred IUPAC name 5-Amino-1-{[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl}-1H-1,2,3-triazole-4-carboxamide | |
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ECHA InfoCard | 100.231.281 |
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InChI
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Properties | |
Chemical formula | C17H12Cl3N5O2 |
Molar mass | 424.66848 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Carboxyamidotriazole is a calcium channel blocker that blocks voltage-gated and ligand-gated calcium channels and has been investigated as an anti-cancer drug in vitro.[1][2]
References
- ^ Figg, W. D.; Cole, K. A.; Reed, E.; Steinberg, S. M.; Piscitelli, S. C.; Davis, P. A.; Soltis, M. J.; Jacob, J.; Boudoulas, S.; Goldspiel, B. (1995). "Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction". Clinical Cancer Research. 1 (8): 797–803. PMID 9816048.
- ^ Bonnefond, M. L.; Florent, R.; Lenoir, S.; Lambert, B.; Abeilard, E.; Giffard, F.; Louis, M. H.; Elie, N.; Briand, M.; Vivien, D.; Poulain, L.; Gauduchon, P.; n'Diaye, M. (2018). "Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BCLXL strategies through MCL-1 down-regulation". Oncotarget. 9 (74): 33896–33911. doi:10.18632/oncotarget.26084. PMC 6188062. PMID 30338034.
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Ion channel modulators
VGKCsTooltip Voltage-gated potassium channels |
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IRKsTooltip Inwardly rectifying potassium channel |
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KCaTooltip Calcium-activated potassium channel |
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K2PsTooltip Tandem pore domain potassium channel |
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VGSCsTooltip Voltage-gated sodium channels |
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ENaCTooltip Epithelial sodium channel |
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ASICsTooltip Acid-sensing ion channel |
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CaCCsTooltip Calcium-activated chloride channel |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator |
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Unsorted |
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TRPsTooltip Transient receptor potential channels |
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LGICsTooltip Ligand gated ion channels |
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators
This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it. |
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