CALML5

Protein-coding gene in the species Homo sapiens
CALML5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2B1U

Identifiers
AliasesCALML5, CLSP, calmodulin like 5
External IDsOMIM: 605183; MGI: 1931464; HomoloGene: 49485; GeneCards: CALML5; OMA:CALML5 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for CALML5
Genomic location for CALML5
Band10p15.1Start5,498,697 bp[1]
End5,499,570 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for CALML5
Genomic location for CALML5
Band13|13 A1Start3,887,757 bp[2]
End3,888,673 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • vulva

  • skin of leg

  • human penis

  • skin of thigh

  • skin of hip

  • skin of arm

  • nipple

  • minor salivary glands

  • parotid gland
Top expressed in
  • lip

  • skin of external ear

  • esophagus

  • belly cord

  • skin of abdomen

  • superior surface of tongue

  • skin of back

  • condyle

  • fossa

  • molar
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • calcium ion binding
  • enzyme regulator activity
Cellular component
  • extracellular region
  • ficolin-1-rich granule lumen
  • nucleus
Biological process
  • signal transduction
  • epidermis development
  • neutrophil degranulation
  • calcium-mediated signaling
  • regulation of catalytic activity
  • spindle pole body organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51806

80796

Ensembl

ENSG00000178372

ENSMUSG00000033765

UniProt

Q9NZT1

Q9JM83

RefSeq (mRNA)

NM_017422

NM_020036

RefSeq (protein)

NP_059118

NP_064420

Location (UCSC)Chr 10: 5.5 – 5.5 MbChr 13: 3.89 – 3.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.[5][6]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178372 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033765 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem. 275 (17): 12841–7. doi:10.1074/jbc.275.17.12841. PMID 10777582.
  6. ^ a b "Entrez Gene: CALML5 calmodulin-like 5".

External links

  • Human CALML5 genome location and CALML5 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q9NZT1 (Human Calmodulin-like protein 5) at the PDBe-KB.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Méhul B, Bernard D, Schmidt R (2001). "Calmodulin-like skin protein: a new marker of keratinocyte differentiation". J. Invest. Dermatol. 116 (6): 905–9. doi:10.1046/j.0022-202x.2001.01376.x. PMID 11407979.
  • Durussel I, Méhul B, Bernard D, et al. (2002). "Cation- and peptide-binding properties of human calmodulin-like skin protein". Biochemistry. 41 (17): 5439–48. doi:10.1021/bi016062z. PMID 11969404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Méhul B, Bernard D, Brouard M, et al. (2006). "Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis". Exp. Dermatol. 15 (6): 469–77. doi:10.1111/j.1600-0625.2006.00433.x. PMID 16689864. S2CID 32717375.
  • Babini E, Bertini I, Capozzi F, et al. (2006). "A structural and dynamic characterization of the EF-hand protein CLSP". Structure. 14 (6): 1029–38. doi:10.1016/j.str.2006.04.004. PMID 16765896.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
  • t
  • e
  • 2b1u: Solution structure of Calmodulin-like Skin Protein C terminal domain
    2b1u: Solution structure of Calmodulin-like Skin Protein C terminal domain


Stub icon

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e