Aminopenicillin
The aminopenicillins are a group of antibiotics in the penicillin family that are structural analogs of ampicillin (which is the 2-amino derivative of benzylpenicillin, hence the name).[1] Like other penicillins and beta-lactam antibiotics, they contain a beta-lactam ring that is crucial to its antibacterial activity.[citation needed]
Aminopenicillins feature a positively charged amino group that enhances their uptake through bacterial porin channels. This does not, however, prevent resistance conferred by bacterial beta-lactamases.[2] Members of this family include ampicillin, amoxicillin and bacampicillin.[3]
See also
- Penicillin
- Extended-spectrum penicillin
- Carboxypenicillin
- β-Lactamase inhibitor
References
- ^ Cunha BA (August 1992). "Aminopenicillins in urology". Urology. 40 (2): 186–90. doi:10.1016/0090-4295(92)90525-2. PMID 1502761.
- ^ Golan, David E. (2011-12-15). Principles of Pharmacology. Philadelphia, PA: Lippincott Williams & Wilkins. ISBN 9781608312702.
- ^ "Mayo Clinic Proceedings". Archived from the original on 2020-05-26. Retrieved 2008-12-26.
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(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases)
Penicillins (Penams) |
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Carbapenems / Penems | |||||||||||||||||
Cephems Cephalosporins Cephamycins Carbacephems |
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Monobactams | |||||||||||||||||
β-lactamase inhibitors |
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Combinations |
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Glycopeptides Lipoglycopeptides |
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Lipopeptides |
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Polymyxins |
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Other |
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- Inhibit PG subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid#
- Teixobactin
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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