Protein-coding gene in the species Homo sapiens
ABCC10 |
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Identifiers |
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Aliases | ABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10 |
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External IDs | OMIM: 612509; MGI: 2386976; HomoloGene: 58616; GeneCards: ABCC10; OMA:ABCC10 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6p21.1 | Start | 43,427,366 bp[1] |
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End | 43,450,427 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17|17 C | Start | 46,614,147 bp[2] |
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End | 46,639,278 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right hemisphere of cerebellum
- granulocyte
- right ovary
- pituitary gland
- anterior pituitary
- right adrenal cortex
- apex of heart
- left ovary
- epithelium of nasopharynx
- right frontal lobe
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| Top expressed in | - substantia nigra
- trigeminal ganglion
- yolk sac
- spermatocyte
- neural layer of retina
- right kidney
- duodenum
- proximal tubule
- ascending aorta
- secondary oocyte
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - nucleotide binding
- ATPase activity
- ATP binding
- ATPase-coupled inorganic anion transmembrane transporter activity
- ATPase-coupled transmembrane transporter activity
| Cellular component | - integral component of membrane
- lysosomal membrane
- plasma membrane
- membrane
- integral component of plasma membrane
| Biological process | - transmembrane transport
- transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001198934 NM_033450 NM_001350518 |
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NM_145140 NM_170680 NM_001347396 |
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RefSeq (protein) | |
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NP_001185863 NP_258261 NP_001337447 |
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NP_001334325 NP_660122 NP_733780 |
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Location (UCSC) | Chr 6: 43.43 – 43.45 Mb | Chr 17: 46.61 – 46.64 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.[5][6]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[6]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000124574 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032842 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
- ^ a b "Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10".
Further reading
- Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily". Cancer Lett. 162 (2): 181–91. doi:10.1016/S0304-3835(00)00646-7. PMID 11146224.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)". Mol. Pharmacol. 63 (2): 351–8. doi:10.1124/mol.63.2.351. PMID 12527806. S2CID 26642179.
- Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7". J. Biomed. Sci. 10 (1): 98–110. doi:10.1159/000068078. PMID 12566991. S2CID 202649323.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404. S2CID 4423608.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
- Hopper-Borge E, Chen ZS, Shchaveleva I, et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel". Cancer Res. 64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID 15256465. S2CID 6933602.
- Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis". J. Immunol. 175 (3): 1383–7. doi:10.4049/jimmunol.175.3.1383. PMID 16034073. S2CID 22554947.
- Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines". Int. J. Oncol. 30 (2): 393–401. doi:10.3892/ijo.30.2.393 (inactive 31 January 2024). PMID 17203221.
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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see also ABC transporter disorders |
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